It turns out that tracrRNA performs two important tasks. First, it facilitates the making of the crRNA, the sequence that carries the memory of a virus that previously attacked the bacteria. Then it serves as a handle to latch on to the invading virus so that the crRNA can target the right spot for the Cas9 enzyme to chop.
This distinction has been described as differentiating task-oriented and process-oriented leadership attributes. The identification of these discrete components of leadership has been empirically documented in laboratory studies of group behavior by psychologists Robert F. Bales and Philip E. Slater.
The idealistic wind of the sixties is still at our backs, though, and most of the people I know who are my age have that ingrained in them forever.
At the front in Germany near the end of the war, McCloy discovered that the ninth-century city of Rothenburg was about to be shelled. McCloy’s mother had once visited the town and brought back etchings; he knew it was an ancient center of German culture. “This is one of Europe’s last great walled cities,” he told the American commander. Perhaps, McCloy suggested, it could be induced to surrender peacefully. It was, and after the war the city voted him an honorary burgher.
As the evening droned on, Einstein turned to a Dutch diplomat seated next to him and said, “I’ve just developed a new theory of eternity.
When Lafayette was first planning his mission, Franklin told him that “much will depend on a prudent and brave sea commander who knows the coasts.” They settled instead for a commander who was, as Franklin was already well aware, more brave than prudent: John Paul Jones.
But they both believed that a divine design was reflected in the elegant laws that governed the way the universe worked.
It was an application of Markkula’s admonition that it was.
From his father, Jobs had learned that a hallmark of a passionate craftmanship is making sure that even the aspects that remain hidden are done beautifully. A great carpenter isn’t gonna use a lousy wood for the back of the cabinet even though nobody’s gonna see it.
He combined two types of lenses to create bifocals and two concepts of representation to foster the nation’s federal compromise.
If I were a young man again and had to decide how to make a living, I would not try to become a scientist or scholar or teacher,” he intoned to Theodore White of the Reporter magazine. “I would rather choose to be a plumber or a peddler, in the hope of finding that modest degree of independence still available.
His success came from questioning conventional wisdom, challenging authority, and marveling at mysteries that struck others as mundane.
Darwin and Wallace had a key trait that is a catalyst for creativity: they had wide-ranging interests and were able to make connections between different disciplines.
The invention of CRISPR and the plague of COVID will hasten our transition to the third great revolution of modern times. These revolutions.
He would aim for simplicity and beauty, and beauty for him was, after all, essentially simplicity.
Nature is the realization of the simplest conceivable mathematical ideas.
A looming ethical issue, everyone at the table agrees, is that gene editing could exacerbate, and even encode, inequality in society.
Scientists who proclaim that space comes to an end somewhere are under some obligation to tell us what lies beyond it.
The Library Company thrives to this day. With 500,000 books and 160,000 manuscripts, it remains a significant historical repository and is the oldest cultural institution in the United States.
It should not be hard for you to look at stains on walls, or the ashes of a fire, or the clouds, or mud, and if you consider them well you will find marvelous new ideas, because the mind is stimulated to new inventions by obscure things.9.