Trying to determine the structure of a protein by UV spectroscopy was like trying to determine the structure of a piano by listening to the sound it made while being dropped down a flight of stairs.
Evolution is cleverer than you are.
Christianity may be OK between consenting adults in private but should not be taught to young children.
It is one of the more striking generalizations of biochemistry – which surprisingly is hardly ever mentioned in the biochemical textbooks – that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.
Almost all aspects of life are engineered at the molecular level, and without understanding molecules we can only have a very sketchy understanding of life itself.
Chance is the only source of true novelty.
It is notoriously difficult to define the word living.
This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.
If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
Again the message to experimentalists is: Be sensible but don’t be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach.
If poly A is added to poly U, to form a double or triple helix, the combination is inactive.
Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.
Anybody who believes that the earth is less than 10,000 years old needs psychiatric help.
A person’s mental activities are entirely due to the behavior of nerve cells, glial cells, and the atoms, ions, and molecules that make them up and influence them.
All approaches at a higher level are suspect until confirmed at the molecular level.
I had discovered the gossip test – what you are really interested in is what you gossip about.
It is amateurs who have one big bright beautiful idea that they can never abandon. Professionals know that they have to produce theory after theory before they are likely to hit the jackpot.
Only gradually did I realize that this lack of qualification could be an advantage. By the time most scientists have reached age thirty they are trapped by their own expertise. They have invested so much effort in one particular field that it is often extremely difficult, at that time in their careers, to make a radical change. I, on the other hand, knew nothing, except for a basic training in somewhat old-fashioned physics and mathematics and an ability to turn my hand to new things. I.
Whatever has a beginning must have an ending.
The hallmark of a successful theory is that it predicts correctly facts that were not known when the theory was presented, or, better still, which were then known incorrectly. A good theory should have at least two characteristics: it should be in sharp contrast to at least one alternative idea and it should make predictions which are testable.